Association between disease progression and depression onset in persons with radiographic knee osteoarthritis.

ABSTRACT:

Objectives

Osteoarthritis (OA) disease progression may lead to deteriorating psychosocial function, but it is unclear what aspects of disease severity are related to the onset of depression. This study assessed which components of OA disease progression cumulatively contribute to depression onset in persons with radiographic knee OA.

Methods

Osteoarthritis Initiative participants (n = 1651) with radiographic disease (Kellgren-Lawrence grade ≥2) in one or both knees and below the screening threshold for probable depression [Center for Epidemiological Studies Depression (CES-D) scale <16] at baseline were included. Disease severity was measured from baseline to the third annual follow-up visit using joint space width, 20-meter gait speed, and the Western Ontario and McMaster U

SUBMITTER: Rathbun AM 

PROVIDER: S-EPMC7590406 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature