Ontology highlight
ABSTRACT:
SUBMITTER: Kameda H
PROVIDER: S-EPMC7590414 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Kameda Hideto H Takeuchi Tsutomu T Yamaoka Kunihiro K Oribe Motohiro M Kawano Mitsuhiro M Zhou Yijie Y Othman Ahmed A AA Pangan Aileen L AL Kitamura Susumu S Meerwein Sebastian S Tanaka Yoshiya Y
Rheumatology (Oxford, England) 20201101 11
<h4>Objective</h4>To evaluate upadacitinib efficacy and safety dose response in Japanese patients with active RA and an inadequate response to conventional synthetic DMARDs (csDMARDs).<h4>Methods</h4>This was a multicentre, phase IIb/III, dose-ranging study conducted in Japan, in which patients on previously stable csDMARDs were randomized to receive upadacitinib 7.5, 15 or 30 mg once daily or matching placebo for a 12-week double-blind period. The primary endpoint was a 20% improvement in ACR c ...[more]