Pubertal timing and breast cancer risk in the Sister Study cohort.

ABSTRACT:

Background

Earlier age at menarche is an established risk factor for breast cancer. While age at menarche has been fairly stable over the past half-century, age at breast development (thelarche) has continued to decrease. Recently, earlier age at thelarche and a longer time between thelarche and menarche (pubertal tempo) were shown to be associated with increased breast cancer risk. Our objective was to examine how breast cancer risk was associated with pubertal timing and tempo in a prospective US cohort.

Methods

Women ages 35-74 years without a history of breast cancer, but who had a sister previously diagnosed with breast cancer, were enrolled in the Sister Study from 2003 to 2009 (N = 50,884). At enrollment, participants reported their ages at thelarche and menarche. Pub

SUBMITTER: Goldberg M 

PROVIDER: S-EPMC7590599 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature