Ontology highlight
ABSTRACT:
SUBMITTER: Huang L
PROVIDER: S-EPMC7590700 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Huang Liling L Jiang Shiyu S Shi Yuankai Y
Journal of hematology & oncology 20201027 1
Tyrosine kinases are implicated in tumorigenesis and progression, and have emerged as major targets for drug discovery. Tyrosine kinase inhibitors (TKIs) inhibit corresponding kinases from phosphorylating tyrosine residues of their substrates and then block the activation of downstream signaling pathways. Over the past 20 years, multiple robust and well-tolerated TKIs with single or multiple targets including EGFR, ALK, ROS1, HER2, NTRK, VEGFR, RET, MET, MEK, FGFR, PDGFR, and KIT have been devel ...[more]