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Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding.


ABSTRACT:

Background

SARS-CoV-2 has spread globally. Currently, literature of SARS-CoV-2 in neonates is scarce. We present a case of a neonate with a high viral load and prolonged virus shedding.

Methods

Epidemiology, clinical characteristics, treatment, laboratory data and follow-up information and the treatment of a neonate with COVID-19 were recorded.

Results

A 7-day-old boy was admitted to the hospital with fever, lethargy and apnoea. He was found SARS-CoV-2 RNA positive with an exceptionally high viral load in nasopharyngeal swab and stool. The father and two maternity nurses at home had detectable SARS-CoV-2 RNA as well. Sequencing showed all strains belonged to the same cluster. The father was asymptomatic and the maternity nurses developed symptoms after visiting. In the mother, no SARS-CoV-2 RNA could be found. Six days after admission, the neonate was discharged after clinical improvement with oral antibiotics because of a possible pyelonephritis. Monitoring the course of this infection showed that SARS-CoV-2 RNA was detectable in the nasopharynx until day 19 and in stool until day 42 after symptom onset.

Conclusions

This case shows that neonates can have a high viral load of SARS-CoV-2 and can shed the virus for over one month in stool. Despite the high viral load in the neonate, the mother and a sibling did not get infected.

SUBMITTER: Slaats MALJ 

PROVIDER: S-EPMC7590917 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding.

Slaats Monique A L J MALJ   Versteylen Maud M   Gast Karin B KB   Oude Munnink Bas B BB   Pas Suzan D SD   Bentvelsen Robbert G RG   van Beek Ron R  

Journal of infection and public health 20201027 12


<h4>Background</h4>SARS-CoV-2 has spread globally. Currently, literature of SARS-CoV-2 in neonates is scarce. We present a case of a neonate with a high viral load and prolonged virus shedding.<h4>Methods</h4>Epidemiology, clinical characteristics, treatment, laboratory data and follow-up information and the treatment of a neonate with COVID-19 were recorded.<h4>Results</h4>A 7-day-old boy was admitted to the hospital with fever, lethargy and apnoea. He was found SARS-CoV-2 RNA positive with an  ...[more]

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