Ontology highlight
ABSTRACT:
SUBMITTER: Dzieszkowski K
PROVIDER: S-EPMC7590975 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Dzieszkowski Krzysztof K Barańska Izabela I Rafiński Zbigniew Z
The Journal of organic chemistry 20200429 10
<i>N</i>-Heterocyclic carbenes (NHCs) catalyzing aza-Claisen rearrangement of α,β-unsaturated enals with cyclic vinylogous amides under oxidative conditions generating potentially biologically active dihydropyridinone-fused uracils have been developed. This strategy represents a unique NHC-activation-based path with the use of 6-aminouracils as stable α,β-diEWG cyclic vinylogous amides for the efficient synthesis of bicyclic <i>N</i>-unprotected lactams similar to those in many useful drugs. ...[more]