Ontology highlight
ABSTRACT:
SUBMITTER: Creighton RL
PROVIDER: S-EPMC7591136 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Creighton Rachel L RL Suydam Ian T IT Ebner Mikaela E ME Afunugo Wilma E WE Bever Alaina M AM Cao Shijie S Jiang Yonghou Y Woodrow Kim A KA
ACS biomaterials science & engineering 20190703 8
Polymeric nanocarriers have been extensively used to improve the delivery of hydrophobic drugs, but often provide low encapsulation efficiency and percent loading for hydrophilic compounds. In particular, insufficient loading of hydrophilic antiretroviral drugs such as the integrase inhibitor raltegravir (RAL) has limited the development of sustained-release therapeutics or prevention strategies against HIV. To address this, we developed a generalizable prodrug strategy using RAL as a model wher ...[more]