Distinct hierarchical alterations of intrinsic neural timescales account for different manifestations of psychosis.

ABSTRACT: Hierarchical perceptual-inference models of psychosis may provide a holistic framework for understanding psychosis in schizophrenia including heterogeneity in clinical presentations. Particularly, hypothesized alterations at distinct levels of the perceptual-inference hierarchy may explain why hallucinations and delusions tend to cluster together yet sometimes manifest in isolation. To test this, we used a recently developed resting-state fMRI measure of intrinsic neural timescale (INT), which reflects the time window of neural integration and captures hierarchical brain gradients. In analyses examining extended sensory hierarchies that we first validated, we found distinct hierarchical INT alterations for hallucinations versus delusions in the auditory and somatosensory systems, thus prov

SUBMITTER: Wengler K 

PROVIDER: S-EPMC7591251 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature