Ontology highlight
ABSTRACT:
SUBMITTER: Abe Y
PROVIDER: S-EPMC7591468 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Abe Yuichi Y Nishimura Yoshiki Y Nakamura Kaori K Tamura Shigehiko S Honsho Masanori M Udo Hiroshi H Yamashita Toshihide T Fujiki Yukio Y
Frontiers in cell and developmental biology 20201014
Peroxisome is an intracellular organelle that functions in essential metabolic pathways including β-oxidation of very-long-chain fatty acids and biosynthesis of plasmalogens. Peroxisome biogenesis disorders (PBDs) manifest severe dysfunction in multiple organs including central nervous system (CNS), whilst the pathogenic mechanisms are largely unknown. We recently reported that peroxisome-deficient neural cells secrete an increased level of brain-derived neurotrophic factor (BDNF), resulting in ...[more]