Ontology highlight
ABSTRACT:
SUBMITTER: Escudero L
PROVIDER: S-EPMC7591522 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Escudero Laura L Llort Anna A Arias Alexandra A Diaz-Navarro Ander A Martínez-Ricarte Francisco F Rubio-Perez Carlota C Mayor Regina R Caratù Ginevra G Martínez-Sáez Elena E Vázquez-Méndez Élida É Lesende-Rodríguez Iván I Hladun Raquel R Gros Luis L Ramón Y Cajal Santiago S Poca Maria A MA Puente Xose S XS Sahuquillo Juan J Gallego Soledad S Seoane Joan J
Nature communications 20201027 1
The molecular characterisation of medulloblastoma, the most common paediatric brain tumour, is crucial for the correct management and treatment of this heterogenous disease. However, insufficient tissue sample, the presence of tumour heterogeneity, or disseminated disease can challenge its diagnosis and monitoring. Here, we report that the cerebrospinal fluid (CSF) circulating tumour DNA (ctDNA) recapitulates the genomic alterations of the tumour and facilitates subgrouping and risk stratificati ...[more]