Glioblastoma Immune Landscape and the Potential of New Immunotherapies.
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ABSTRACT:
SUBMITTER: Daubon T
PROVIDER: S-EPMC7591769 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Glioblastoma Immune Landscape and the Potential of New Immunotherapies.
Daubon Thomas T Hemadou Audrey A Romero Garmendia Irati I Saleh Maya M
Frontiers in immunology 20201014
Glioblastoma (GBM) are the most common tumors of the central nervous system and among the deadliest cancers in adults. GBM overall survival has not improved over the last decade despite optimization of therapeutic standard-of-care. While immune checkpoint inhibitors (ICI) have revolutionized cancer care, they unfortunately have little therapeutic success in GBM. Here, we elaborate on normal brain and GBM-associated immune landscapes. We describe the role of microglia and tumor-associated macroph ...[more]
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