Ontology highlight
ABSTRACT:
SUBMITTER: Zhou L
PROVIDER: S-EPMC7591870 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
iScience 20201028 11
The cellular targets of SARS-CoV-2, the novel coronavirus causing the COVID-19 pandemic, is still rudimentary. Here, we incorporated the protein information to analyze the expression of ACE2, the SARS-CoV-2 receptor, together with co-factors, TMPRSS2 and Furin, at single-cell level <i>in situ</i>, which we called protein-proofed single-cell RNA (pscRNA) profiling. Systemic analysis across 36 tissues revealed a rank list of candidate cells potentially vulnerable to SARS-CoV-2. The top targets are ...[more]