Ontology highlight
ABSTRACT:
SUBMITTER: Crawford T
PROVIDER: S-EPMC7591906 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Crawford Troy T Moshnikova Anna A Roles Sean S Weerakkody Dhammika D DuPont Michael M Carter Lukas M LM Shen John J Engelman Donald M DM Lewis Jason S JS Andreev Oleg A OA Reshetnyak Yana K YK
Scientific reports 20201027 1
Fluorescence imaging has seen enduring use in blood flow visualization and is now finding a new range of applications in image-guided surgery. In this paper, we report a translational study of a new fluorescent agent for use in surgery, pHLIP ICG, where ICG (indocyanine green) is a surgical fluorescent dye used widely for imaging blood flow. We studied pHLIP ICG interaction with the cell membrane lipid bilayer, the pharmacology and toxicology in vitro and in vivo (mice and dogs), and the biodist ...[more]