Ontology highlight
ABSTRACT:
SUBMITTER: Hurlburt NK
PROVIDER: S-EPMC7591918 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Nature communications 20201027 1
SARS-CoV-2 is a betacoronavirus virus responsible for the COVID-19 pandemic. Here, we determine the X-ray crystal structure of a potent neutralizing monoclonal antibody, CV30, isolated from a patient infected with SARS-CoV-2, in complex with the receptor binding domain. The structure reveals that CV30 binds to an epitope that overlaps with the human ACE2 receptor binding motif providing a structural basis for its neutralization. CV30 also induces shedding of the S1 subunit, indicating an additio ...[more]