Association Between Preoperative Benzodiazepine Use and Postoperative Opioid Use and Health Care Costs.

ABSTRACT: Importance:The association between preoperative benzodiazepine use and long-term postoperative outcomes is not well understood. Objective:To characterize the association between preoperative benzodiazepine use and postoperative opioid use and health care costs. Design, Setting, and Participants:In this cohort study, retrospective analysis of private health insurance claims data on 946?561 opioid-naive patients (no opioid prescriptions filled in the year before surgery) throughout the US was conducted. Patients underwent 1 of 11 common surgical procedures between January 1, 2004, and December 31, 2016; data analysis was performed January 9, 2020. Exposures:Benzodiazepine use, defined as long term (?10 prescriptions filled or ?120 days supplied in the year before surgery) or intermittent (any use not meeting the criteria for long term). Main Outcomes and Measures:The primary outcome was opioid use 91 to 365 days after surgery. Secondary outcomes included opioid use 0 to 90 days after surgery and health care costs 0 to 30 days after surgery. Results:In this sample of 946?561 patients, the mean age was 59.8 years (range, 18-89 years); 615?065 were women (65.0%). Of these, 23?484 patients (2.5%) met the criteria for long-term preoperative benzodiazepine use and 47?669 patients (5.0%) met the criteria for intermittent use. After adjusting for confounders, long-term (odds ratio [OR], 1.59; 95% CI, 1.54-1.65; P?

SUBMITTER: Rishel CA 

PROVIDER: S-EPMC7592026 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature