Ontology highlight
ABSTRACT:
SUBMITTER: Karimi Askarani H
PROVIDER: S-EPMC7592376 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Karimi Askarani Hajar H Iraji Aida A Rastegari Arezoo A Abbas Bukhari Syed Nasir SN Firuzi Omidreza O Akbarzadeh Tahmineh T Saeedi Mina M
BMC chemistry 20201027 1
To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a new series of 1,2,3-triazole-chromenone derivatives were designed and synthesized based on the multi target-directed ligands approach. The in vitro biological activities included acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition as well as anti-Aβ aggregation, neuroprotective effects, and metal-chelating properties. The results indicated a highly selective BuChE inhibitory activity with an ...[more]