The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Tang B
PROVIDER: S-EPMC7592541 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma.
Tang Bufu B Zhu Jinyu J Li Jie J Fan Kai K Gao Yang Y Cheng Shimiao S Kong Chunli C Zheng Liyun L Wu Fazong F Weng Qiaoyou Q Lu Chenying C Ji Jiansong J
Cell communication and signaling : CCS 20201028 1
<h4>Background</h4>In this study, we comprehensively analyzed genes related to ferroptosis and iron metabolism to construct diagnostic and prognostic models and explore the relationship with the immune microenvironment in HCC.<h4>Methods</h4>Integrated analysis, cox regression and the least absolute shrinkage and selection operator (LASSO) method of 104 ferroptosis- and iron metabolism-related genes and HCC-related RNA sequencing were performed to identify HCC-related ferroptosis and iron metabo ...[more]
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