Ontology highlight
ABSTRACT: Background
The link between cholesterol and Alzheimer's disease (AD) has received much attention, as evidence suggests high levels of cholesterol might be an AD risk factor. The carriage of cholesterol and lipids through the body is mediated via lipoproteins, some of which, particularly apolipoprotein E (ApoE), are intimately linked with AD. In humans, high density lipoprotein (HDL) is regarded as a "good" lipid complex due to its ability to enable clearance of excess cholesterol via 'cholesterol reverse transport', although its activities in the pathogenesis of AD are poorly understood. There are several subclasses of HDL; these range from the newly formed small HDL, to much larger HDL.Objective
We examined the major subclasses of HDL in healthy controls, mild cognitively impaired, and AD patients who were not taking statins to determine whether there were HDL profile differences between the groups, and whether HDL subclass levels correlated with plasma amyloid-? (A?) levels or brain A? deposition.Methods
Samples from AIBL cohort were used in this study. HDL subclass levels were assessed by Lipoprint while A?1-42 levels were assessed by ELISA. Brain A? deposition was assessed by PET scan. Statistical analysis was performed using parametric and non-parametric tests.Results
We found that small HDL subclass is reduced in AD patients and it correlates with cognitive performance while plasma A? concentrations do not correlate with lipid profile or HDL subfraction levels.Conclusion
Our data indicate that AD patients exhibit altered plasma HDL profile and that HDL subclasses correlate with cognitive performances.
SUBMITTER: Pedrini S
PROVIDER: S-EPMC7592676 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Journal of Alzheimer's disease : JAD 20200101 2
<h4>Background</h4>The link between cholesterol and Alzheimer's disease (AD) has received much attention, as evidence suggests high levels of cholesterol might be an AD risk factor. The carriage of cholesterol and lipids through the body is mediated via lipoproteins, some of which, particularly apolipoprotein E (ApoE), are intimately linked with AD. In humans, high density lipoprotein (HDL) is regarded as a "good" lipid complex due to its ability to enable clearance of excess cholesterol via 'ch ...[more]