Dataset Information

Association of miR-4293 rs12220909 polymorphism with cancer risk: A meta-analysis of 8394 subjects.

ABSTRACT: BACKGROUND:Several studies have investigated miR-4293 rs12220909 polymorphisms and cancer susceptibility and yielded different results. Because of this controversy, we designed a meta-analysis to assess comprehensively the association of the rs12220909 polymorphism with cancer risk. METHODS:Relevant articles were collected by searching the databases of PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and WanFang. Data on rs12220909 in cancer patients and controls were extracted. Sensitivity analyses and publication bias assessments were performed. RESULTS:Five studies with 3820 cases and 4574 controls were included in our meta-analysis. Pooled analyses showed that the rs12220909 polymorphism was not associated with cancer risk in any genetic model. (C vs G: odds ratio [OR]?=?0.89, 95% confidence interval [CI]?=?0.74-1.07; GC vs GG: OR?=?0.83, 95% CI?=?0.67-1.03; CC vs GG: OR?=?1.06, 95% CI?=?0.82-1.36; CC+GC vs GG: OR?=?0.84, 95% CI?=?0.69-1.03; CC vs GC+GG: OR?=?1.10, 95% CI?=?0.85-1.40). CONCLUSIONS:Our results indicate that rs12220909 is not associated with cancer risk. Larger, well-designed multicenter studies are needed to further explore the association of miR-4293 rs12220909 polymorphism with cancer risk.

SUBMITTER: Liu R

PROVIDER: S-EPMC7593050 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Association of miR-4293 rs12220909 polymorphism with cancer risk: A meta-analysis of 8394 subjects.

Liu Rongqiang R Fu Hongyuan H Yu Yajie Y Xu Qianhui Q Fang Jiangwen J Ge Qianmin Q Shao Yi Y

Medicine 20200801 32

<h4>Background</h4>Several studies have investigated miR-4293 rs12220909 polymorphisms and cancer susceptibility and yielded different results. Because of this controversy, we designed a meta-analysis to assess comprehensively the association of the rs12220909 polymorphism with cancer risk.<h4>Methods</h4>Relevant articles were collected by searching the databases of PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and WanFang. Data on rs12220909 in cancer patients ...[more]

PMID: 32769868

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Project description:To systematically evaluate the association between the miR-146a rs2910164 polymorphism and susceptibility to gastric cancer.A comprehensive electronic search was conducted for articles published up until January 27, 2014 in Medline (PubMed), Excerpta Medica Database (Embase), the Cochrane Library and Google Scholar. Only case-control studies published in English that evaluated the association between the miR-146a rs2910164 polymorphism and susceptibility to gastric cancer were included. Furthermore, only studies with sufficient data allowing for calculation of odds ratio (OR) and corresponding 95% confidence interval (CI) were included. These values were used in the quantitative synthesis to assess the strength of the association between the miR-146a rs2910164 polymorphism and risk of gastric cancer.The database search identified 1002 eligible studies, of which seven (comprising 4112 cases and 5811 controls) were included for the meta-analysis. The results indicate that miR-146a rs2910164 polymorphism is more likely to be associated with gastric cancer risk. In the overall analysis, a significantly increased cancer risk was found in the heterozygote (GG vs GC) comparison (OR = 1.14, 95%CI: 1.03-1.27; P = 0.01 for pooled OR). In the ethnicity subgroup analysis, a similar result was found among Caucasians (OR = 1.36, 95%CI: 1.01-1.85; P = 0.04 for pooled OR). In the stratified analysis by quality of studies, a significantly increased cancer risk was found in the heterozygote comparison among high quality studies (OR = 1.12, 95%CI: 1.01-1.26; P = 0.04 for pooled OR). When stratified on the basis of sample size, a significantly increased cancer risk was found among small sample size subgroups for the allelic (G vs C: OR = 1.16, 95%CI: 1.03-1.30; P = 0.01), homozygote (GG vs CC: OR = 1.33, 95%CI: 1.03-1.73; P = 0.03) and recessive model (GG vs GC + CC: OR = 0.05, 95%CI: 0.00-0.10; P = 0.03) comparisons.The miR-146a rs2910164 polymorphism is associated with increased gastric cancer risk, particularly evident in high quality studies with small sample sized Caucasian populations.

Dataset Information

Association of miR-4293 rs12220909 polymorphism with cancer risk: A meta-analysis of 8394 subjects.

Publications

Association of miR-4293 rs12220909 polymorphism with cancer risk: A meta-analysis of 8394 subjects.

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