Dataset Information

[Iodine-rich thermal water in cure and rehabilitation from the perspective of the thyroid gland].

ABSTRACT: Excessive iodine intake should be avoided in certain thyroid disorders, such as Graves' disease, Hashimoto's thyroiditis and thyroid goiter with autonomous nodules. Regarding alimentary iodine intake broad information can be found in the literature or the internet. Cure and rehabilitation therapy is used in many clinical settings, such as chronic degenerative disorders of the musculoskeletal system, rehabilitation after trauma, after treatment of malignant tumors and many others. Iodine intake with iodine-rich thermal water during cure and rehabilitation is possible and the extent depends in particular on the route of application and the duration of treatment. Information on this topic can be hardly found in the literature. This article analyses iodine-rich cure and rehabilitation treatment with iodine-rich thermal water from the point of view of the thyroid gland. The positive and possible negative effects of treatment with iodine-rich thermal water on thyroid function are elucidated. Apart from an insight into the physiology and pathophysiology of iodine metabolism, the extent of iodine intake during cure and rehabilitation treatment is presented depending on the route of application and the clinical implications for certain thyroid disorders are discussed. An overview of cure and rehabilitation centers in Austria and neighboring countries is given. In addition, an algorithm for the clinical selection of patients unsuitable for high iodine intake and who should thus avoid an iodine-rich cure or rehabilitation treatment is presented in order to assist clinicians in optimally selecting patients for cure or rehabilitation treatment with iodine-rich thermal water.

SUBMITTER: Mikosch P

PROVIDER: S-EPMC7593323 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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[Iodine-rich thermal water in cure and rehabilitation from the perspective of the thyroid gland].

Mikosch Peter P Trifina-Mikosch Eva E Saidler Katharina K Kellner Jennifer J Suhrau Susanne S

Wiener medizinische Wochenschrift (1946) 20201007 15-16

Excessive iodine intake should be avoided in certain thyroid disorders, such as Graves' disease, Hashimoto's thyroiditis and thyroid goiter with autonomous nodules. Regarding alimentary iodine intake broad information can be found in the literature or the internet. Cure and rehabilitation therapy is used in many clinical settings, such as chronic degenerative disorders of the musculoskeletal system, rehabilitation after trauma, after treatment of malignant tumors and many others. Iodine intake w ...[more]

PMID: 33026541

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Project description:Introduction Iodine-131 (131I) is frequently used in nuclear medicine. Unbound or released 131I accumulate in the thyroid gland and may be detrimental to normal thyroid function. The aim of the present study was to identify biomarkers for 131I exposure in rat thyroid tissue and to assess the effect on thyroid function. Methods Thirty six male Sprague Dawley rats were i.v. injected with 150 µl saline solution containing 9.0, 88, 170, 260, 340, 760, 1300, or 4700 kBq (group A-H) 131I, or mock-treated with 150 µl saline solution only, and killed at 24 h after injection. Total RNA was extracted from individual thyroid tissue samples thyroids and mRNA levels were determined with the Agilent microarray platform. Results Estimated absorbed doses in treatment groups A-H was 0.0058, 0.057, 0.11, 0.17, 0.22, 0.5 Gy, 0.8 Gy, and 3 Gy. Totally, 429 transcripts were identified with a fold change fold change ≥ 1.5 and adjusted p-value ≤ 0.01. A trend with downregulation of thyroid hormone biosynthesis associated genes (e.g. thyroglobulin, thyroid peroxidase, the sodium-iodine symporter) was identified, but only statistically significant after 0.0058 and 0.22 Gy. Three transcripts coding for isoform 1 of the DBP protein showed a pattern with monotonous decrease in downregulation with absorbed dose between 0.0058-0.22 Gy. Changes in Dbp expression were not statistically significant between 0.5-3 Gy. However, a trend with downregulation at 0.5 and 0.8 Gy and upregulation and 3 Gy was identified. Previously, 131I (0.85-17 Gy) and 211At (0.023-32 Gy) exposure resulted in upregulation of Dbp in mice thyroid tissue 24 h after administrations. Additionally, a monotonous decrease in Dbp downregulation has been identified of in mouse kidney tissue at 8 and 12 months after 177Lu-octreotate administrations. Conclusion Conclusively, the Dbp gene is a promising candidate biomarker gene for exposure to 131I and possibly other internal radiation emitters. Further studies should be performed to establish how Dbp expression vary with dose-rate, absorbed dose, time after administration, different radiation qualities, and the function of Dbp.

Project description:Introduction Iodine-131 (131I) is frequently used in nuclear medicine. Unbound or released 131I accumulate in the thyroid gland and may be detrimental to normal thyroid function. The aim of the present study was to identify biomarkers for 131I exposure in rat thyroid tissue and to assess the effect on thyroid function. Methods Thirty six male Sprague Dawley rats were i.v. injected with 150 Âµl saline solution containing 9.0, 88, 170, 260, 340, 760, 1300, or 4700 kBq (group A-H) 131I, or mock-treated with 150 Âµl saline solution only, and killed at 24 h after injection. Total RNA was extracted from individual thyroid tissue samples thyroids and mRNA levels were determined with the Agilent microarray platform. Results Estimated absorbed doses in treatment groups A-H was 0.0058, 0.057, 0.11, 0.17, 0.22, 0.5 Gy, 0.8 Gy, and 3 Gy. Totally, 429 transcripts were identified with a fold change fold change â¥ 1.5 and adjusted p-value â¤ 0.01. A trend with downregulation of thyroid hormone biosynthesis associated genes (e.g. thyroglobulin, thyroid peroxidase, the sodium-iodine symporter) was identified, but only statistically significant after 0.0058 and 0.22 Gy. Three transcripts coding for isoform 1 of the DBP protein showed a pattern with monotonous decrease in downregulation with absorbed dose between 0.0058-0.22 Gy. Changes in Dbp expression were not statistically significant between 0.5-3 Gy. However, a trend with downregulation at 0.5 and 0.8 Gy and upregulation and 3 Gy was identified. Previously, 131I (0.85-17 Gy) and 211At (0.023-32 Gy) exposure resulted in upregulation of Dbp in mice thyroid tissue 24 h after administrations. Additionally, a monotonous decrease in Dbp downregulation has been identified of in mouse kidney tissue at 8 and 12 months after 177Lu-octreotate administrations. Conclusion Conclusively, the Dbp gene is a promising candidate biomarker gene for exposure to 131I and possibly other internal radiation emitters. Further studies should be performed to establish how Dbp expression vary with dose-rate, absorbed dose, time after administration, different radiation qualities, and the function of Dbp. Total RNA was isolated from fresh-frozen individual thyroid tissue samples (Sprague Dawley rats). Each sample was run once. Four rats received the same treatment. Control samples (from non-irradiated rats) are included.

Dataset Information

[Iodine-rich thermal water in cure and rehabilitation from the perspective of the thyroid gland].

Publications

[Iodine-rich thermal water in cure and rehabilitation from the perspective of the thyroid gland].

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