Ontology highlight
ABSTRACT:
SUBMITTER: Wolfsgruber A
PROVIDER: S-EPMC7594070 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20201011 20
The scope of a series of <i>N</i>-alkylated iminosugar based inhibitors in the d-<i>gluco</i> as well as d-<i>xylo</i> configuration towards their interaction with human lysosomal β-glucocerebrosidase has been evaluated. A versatile synthetic toolbox has been developed for the synthesis of <i>N</i>-alkylated iminosugar scaffolds conjugated to a variety of terminal groups via a benzoic acid ester linker. The terminal groups such as nitrile, azide, alkyne, nonafluoro-<i>tert</i>-butyl and amino su ...[more]