Rescue treatment with eltrombopag in refractory cytopenias after allogeneic stem cell transplantation.

ABSTRACT:

Background

Patients with post-transplant cytopenias due to poor graft function or primary engraftment failure show poor prognosis with a high mortality rate mainly because of graft versus host disease (GVHD), infection and/or bleeding. Treatment options are scarce and a CD34+ stem cell boost or a second bone marrow transplantation may be required to restore adequate haematopoiesis.

Methods

In the present study patients with primary engraftment failure (n = 1) and refractory poor graft function (n = 11) were treated with eltrombopag in a single centre. The reason for eltrombopag treatment was trilineage cytopenia in six patients, bilineage cytopenia in three patients and single lineage cytopenia in three patients. Eltrombopag was initiated at a median of

SUBMITTER: Aydin S 

PROVIDER: S-EPMC7594218 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature