Ontology highlight
ABSTRACT:
SUBMITTER: Mascarenhas JO
PROVIDER: S-EPMC7594401 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Mascarenhas John O JO Rampal Raajit K RK Kosiorek Heidi E HE Bhave Rupali R Hexner Elizabeth E Wang Eunice S ES Gerds Aaron A Abboud Camille N CN Kremyanskaya Marina M Berenzon Dimitry D Odenike Olatoyosi O Farnoud Noushin N Krishnan Aishwarya A Weinberg Rona Singer RS McGovern Erin E Salama Mohamed E ME Najfeld Vesna V Medina-Martinez Juan S JS Arango Ossa Juan E JE Levine Max F MF Zhou Yangyu Y Sandy Lonette L Heaney Mark L ML Levine Ross L RL Mesa Ruben A RA Dueck Amylou C AC Hoffman Ronald R
Blood advances 20201001 20
Myeloproliferative neoplasms (MPN) that have evolved into accelerated or blast phase disease (MPN-AP/BP) have poor outcomes with limited treatment options and therefore represent an urgent unmet need. We have previously demonstrated in a multicenter, phase 1 trial conducted through the Myeloproliferative Neoplasms Research Consortium that the combination of ruxolitinib and decitabine is safe and tolerable and is associated with a favorable overall survival (OS). In this phase 2 trial, 25 patient ...[more]