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Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions.

ABSTRACT: Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

SUBMITTER: Wen PY 

PROVIDER: S-EPMC7594557 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions.

Wen Patrick Y PY   Weller Michael M   Lee Eudocia Quant EQ   Alexander Brian M BM   Barnholtz-Sloan Jill S JS   Barthel Floris P FP   Batchelor Tracy T TT   Bindra Ranjit S RS   Chang Susan M SM   Chiocca E Antonio EA   Cloughesy Timothy F TF   DeGroot John F JF   Galanis Evanthia E   Gilbert Mark R MR   Hegi Monika E ME   Horbinski Craig C   Huang Raymond Y RY   Lassman Andrew B AB   Le Rhun Emilie E   Lim Michael M   Mehta Minesh P MP   Mellinghoff Ingo K IK   Minniti Giuseppe G   Nathanson David D   Platten Michael M   Preusser Matthias M   Roth Patrick P   Sanson Marc M   Schiff David D   Short Susan C SC   Taphoorn Martin J B MJB   Tonn Joerg-Christian JC   Tsang Jonathan J   Verhaak Roel G W RGW   von Deimling Andreas A   Wick Wolfgang W   Zadeh Gelareh G   Reardon David A DA   Aldape Kenneth D KD   van den Bent Martin J MJ  

Neuro-oncology 20200801 8

Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase w  ...[more]

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