Ontology highlight
ABSTRACT:
SUBMITTER: Tarbier M
PROVIDER: S-EPMC7595044 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Tarbier Marcel M Mackowiak Sebastian D SD Frade João J Catuara-Solarz Silvina S Biryukova Inna I Gelali Eleni E Menéndez Diego Bárcena DB Zapata Luis L Ossowski Stephan S Bienko Magda M Gallant Caroline J CJ Friedländer Marc R MR
Nature communications 20201028 1
Single-cell RNA sequencing studies on gene co-expression patterns could yield important regulatory and functional insights, but have so far been limited by the confounding effects of differentiation and cell cycle. We apply a tailored experimental design that eliminates these confounders, and report thousands of intrinsically covarying gene pairs in mouse embryonic stem cells. These covariations form a network with biological properties, outlining known and novel gene interactions. We provide th ...[more]