Ontology highlight
ABSTRACT:
SUBMITTER: Kunz V
PROVIDER: S-EPMC7595222 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Kunz Viktoria V Bommert Kathryn S KS Kruk Jessica J Schwinning Daniel D Chatterjee Manik M Stühmer Thorsten T Bargou Ralf R Bommert Kurt K
Scientific reports 20201028 1
Experimental evidence suggests that ubiquitin-protein ligases regulate a number of cellular processes involved in tumorigenesis. We analysed the role of the E3 ubiquitin-protein ligase HUWE1 for pathobiology of multiple myeloma (MM), a still incurable blood cancer. mRNA expression analysis indicates an increase in HUWE1 expression levels correlated with advanced stages of myeloma. Pharmacologic as well as RNAi-mediated HUWE1 inhibition caused anti-proliferative effects in MM cell lines in vitro ...[more]