Ontology highlight
ABSTRACT:
SUBMITTER: Caggiano C
PROVIDER: S-EPMC7595235 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Caggiano Cinzia C Guida Eugenia E Todaro Federica F Bielli Pamela P Mori Mattia M Ghirga Francesca F Quaglio Deborah D Botta Bruno B Moretti Fabiola F Grimaldi Paola P Rossi Pellegrino P Jannini Emmanuele A EA Barchi Marco M Dolci Susanna S
Cell death discovery 20201028 1
In the search of small molecules that can target MDM2/p53 pathway in testicular germ cell tumors (TGCTs), we identified sempervirine (2,3,4,13-tetrahydro-1H-benz[g]indolo[2,3-a]quinolizin-6-ium), an alkaloid of Gelsemium sempervirens, that has been previously proposed as an inhibitor of MDM2 that targets p53-wildtype (wt) tumor cells. We found that sempervirine not only affects cell growth of p53-wt cancer cells, but it is also active in p53-mutated and p53-null cells by triggering p53-dependent ...[more]