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The Association of Matrix Metalloproteinase Gene Polymorphisms and Periodontitis: An Overview.

ABSTRACT: Periodontitis is a multifactorial inflammatory disease, pathogenic bacteria being the primary etiological agents. The host response and the severity of clinical manifestation are determined by genetic and environmental factors. There is some evidence that the individual response to environmental variations in the immune response in periodontitis is associated with genetic factors. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes located in the extracellular matrix. Their primary function is the breakdown of connective tissue components. Their role in the oral cavity is very vital. In this literature review, we summarized the contemporary knowledge on the function of MMPs in oral cavity and periodontal disease.

SUBMITTER: Alotaibi DH

PROVIDER: S-EPMC7595482 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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The Association of Matrix Metalloproteinase Gene Polymorphisms and Periodontitis: An Overview.

Alotaibi Dalal H DH Altalhi Abdulaziz Mohammed AM Sambawa Zainah Mohammed ZM Koppolu Pradeep P Alsinaidi Aljoharah Abdullah AA Krishnan Preeti P

Journal of pharmacy & bioallied sciences 20200828 Suppl 1

Periodontitis is a multifactorial inflammatory disease, pathogenic bacteria being the primary etiological agents. The host response and the severity of clinical manifestation are determined by genetic and environmental factors. There is some evidence that the individual response to environmental variations in the immune response in periodontitis is associated with genetic factors. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes located in the extracellular matrix. Their prim ...[more]

PMID: 33149428

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