Ontology highlight
ABSTRACT:
SUBMITTER: Guintivano J
PROVIDER: S-EPMC7595582 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Guintivano Jerry J Shabalin Andrey A AA Chan Robin F RF Rubinow David R DR Sullivan Patrick F PF Meltzer-Brody Samantha S Aberg Karolina A KA van den Oord Edwin J C G EJCG
Epigenetics 20200519 11
Recent years have seen a surge of methylome-wide association studies (MWAS). We observed that many of these studies suffer from test statistic inflation that is most likely caused by commonly used quality control (QC) pipelines not going far enough to remove technical artefacts. To support this claim, we reanalysed GEO datasets with an improved QC pipeline that reduced test-statistic inflation parameter lambda from the original mean/median of 20.16/15.17 to 3.07/1.14. Furthermore, the mean/media ...[more]