Ontology highlight
ABSTRACT:
SUBMITTER: Symmank J
PROVIDER: S-EPMC7595593 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Symmank Judit J Bayer Cathrin C Reichard Julia J Pensold Daniel D Zimmer-Bensch Geraldine G
Epigenetics 20200522 11
Apart from the conventional view of repressive promoter methylation, the DNA methyltransferase 1 (DNMT1) was recently described to modulate gene expression through a variety of interactions with diverse epigenetic key players. We here investigated the DNMT1-dependent transcriptional control of the homeobox transcription factor LHX1, which we previously identified as an important regulator in cortical interneuron development. We found that LHX1 expression in embryonic interneurons originating in ...[more]