Oral cancer cell?derived exosomes modulate natural killer cell activity by regulating the receptors on these cells.
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ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC7595664 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Oral cancer cell‑derived exosomes modulate natural killer cell activity by regulating the receptors on these cells.
Zhu Xueqin X Qin Xing X Wang Xiaoning X Wang Yingnan Y Cao Wei W Zhang Jianjun J Chen Wantao W
International journal of molecular medicine 20200924 6
Oral cancer (OC) is the most common type of head and neck malignant tumor. Tumor‑derived exosomes induce a complex extracellular environment that affects tumor immunity. In the present study, exosomes were isolated from OC cell lines (WSU‑HN4 and SCC‑9) by ultrafiltration and the protein content of these oral cancer‑derived exosomes (OCEXs) was analyzed by mass spectrometry, which revealed the enrichment of transforming growth factor (TGF)‑β1. Natural killer (NK) cells were examined by flow cyto ...[more]
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