Dataset Information

Circulating CD56+ NKG2D+ NK cells and postoperative fertility in ovarian endometrioma.

ABSTRACT: The current biomarkers for postoperative fertility assessment caused by ovarian endometrioma (OE) are insufficient. The present study hypothesized that the peripheral lymphocyte subpopulation can be used as a candidate biomarker of postoperative infertility in OE. The association of the number of circulating CD4/CD8 T, NK, and ?? T cells with postoperative fertility was assessed in 33 OE patients aged 20?~?40 years between June 2018 and January 2019. Concomitantly, 68 healthy female subjects were recruited. The changes in the baseline immune characteristics between the two groups were compared. The data demonstrated significant differences in the ratio of CD4/CD8 T cells and the number of CD56+ NKG2D+ NK cells and ?? T cells between OE patients and control subjects. The patients were followed-up till December 2019 and the number of CD56+ NKG2D+ NK cells in the cases was a significant predictor for postoperative fertility as determined by different COX regression models (crude HR?=?0.220, 95% CI?=?0.059-0.822; adjusted HR?=?0.127, 95% CI?=?0.024-0.675). A significant delay to successful pregnancy was noted in OE patients (median time, 173 vs. 99 days, log-rank P?=?0.013). The present findings suggested that CD56+ NKG2D+ NK cells are a candidate biomarker of postoperative fertility in OE patients. Larger population studies are warranted.

SUBMITTER: Liu ZQ

PROVIDER: S-EPMC7596045 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Circulating CD56+ NKG2D+ NK cells and postoperative fertility in ovarian endometrioma.

Liu Zhi-Qin ZQ Lu Mei-Yin MY Liu Bin B

Scientific reports 20201029 1

The current biomarkers for postoperative fertility assessment caused by ovarian endometrioma (OE) are insufficient. The present study hypothesized that the peripheral lymphocyte subpopulation can be used as a candidate biomarker of postoperative infertility in OE. The association of the number of circulating CD4/CD8 T, NK, and γδ T cells with postoperative fertility was assessed in 33 OE patients aged 20 ~ 40 years between June 2018 and January 2019. Concomitantly, 68 healthy female subjects wer ...[more]

PMID: 33122818

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Project description:BackgroundThe efficacy of hormonal regimens for the prevention of endometrioma recurrence in women who have undergone conservative surgery is still controversial.ObjectiveTo compare the efficacy of different hormonal regimens in this context and to rank them.Search strategyMEDLINE and Scopus databases were searched through January 2020.Selection criteriaRandomised controlled trials (RCTs) or cohorts, comparing the effect of any pair of interventions (i.e. cyclic oral contraceptives [OC], continuous OC, gonadotropin-releasing hormone agonist [GnRHa], dienogest [DNG], levonorgestrel-releasing intrauterine system [LNG-IUS] and expectant management) on endometrioma recurrence were selected.Data collection and analysisData were independently extracted by two reviewers. Relative treatment effects were estimated using network meta-analysis (NMA) and ranked in descending order.Main resultsSix RCTs (675 patients) and 16 cohorts (3089 patients) were included. NMA of the RCTs involving expectant management, cyclic OC, continuous OC, GnRHa and GnRHa + LNG-IUS, showed that all hormonal regimens had a nonsignificant lower risk of endometrioma recurrence compared with expectant management. NMA of the cohorts involving expectant, cyclic OC, continuous OC, GnRHa, DNG, LNG-IUS, GnRHa + OC, and GnRHa + LNG-IUS indicated that LNG-IUS, DNG, continuous OC, GnRHa + OC and cyclic OC had a significantly lower risk of endometrioma recurrence than expectant management. LNG-IUS was ranked highest, followed by DNG and GnRHa + LNG-IUS. Long-term use of hormonal treatment either OC or progestin had a significantly lower risk of endometrioma recurrence than expectant treatment.ConclusionIn the NMA of RCTs, there was no evidence supporting hormonal treatment for postoperative prevention of endometrioma recurrence. This was at odds with the cohort evidence, which found the protective effect of OC and progestin regimens, especially long-term treatment. Large-scale RCTs of these agents are still required.Tweetable abstractHormonal regimens given as long-term treatment tend to reduce risk of endometrioma recurrence after conservative surgery.

Dataset Information

Circulating CD56+ NKG2D+ NK cells and postoperative fertility in ovarian endometrioma.

Publications

Circulating CD56+ NKG2D+ NK cells and postoperative fertility in ovarian endometrioma.

Similar Datasets

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