Metabolic network as an objective biomarker in monitoring deep brain stimulation for Parkinson's disease: a longitudinal study.

ABSTRACT:

Background

With the advance of subthalamic nucleus (STN) deep brain stimulation (DBS) in the treatment of Parkinson's disease (PD), it is desired to identify objective criteria for the monitoring of the therapy outcome. This paper explores the feasibility of metabolic network derived from positron emission tomography (PET) with ¹⁸F-fluorodeoxyglucose in monitoring the STN DBS treatment for PD.

Methods

Age-matched 33 PD patients, 33 healthy controls (HCs), 9 PD patients with bilateral DBS surgery and 9 controls underwent ¹⁸F-FDG PET scans. The DBS patients were followed longitudinally to investigate the alternations of the PD-related metabolic covariance pattern (PDRP) expressions.

Results

The PDRP expression was abnormally elevated in PD patients

SUBMITTER: Ge J 

PROVIDER: S-EPMC7596139 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature