Transdermal Delivery of Kidney-Targeting Nanoparticles Using Dissolvable Microneedles.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) affects approximately 13% of the world's population and will lead to dialysis or kidney transplantation. Unfortunately, clinically available drugs for CKD show limited efficacy and toxic extrarenal side effects. Hence, there is a need to develop targeted delivery systems with enhanced kidney specificity that can also be combined with a patient-compliant administration route for such patients that need extended treatment. Towards this goal, kidney-targeted nanoparticles administered through transdermal microneedles (KNP/MN) is explored in this study.

Methods

A KNP/MN patch was developed by incorporating folate-conjugated micelle nanoparticles into polyvinyl alcohol MN patches. Rhodamine B (RhB) was encapsulated into KNP as a model dru

SUBMITTER: Tripathy N 

PROVIDER: S-EPMC7596160 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature