Antioxidant Function and Metabolomics Study in Mice after Dietary Supplementation with Methionine.
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ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC7596454 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Antioxidant Function and Metabolomics Study in Mice after Dietary Supplementation with Methionine.
Yu Manrong M Chen Hui H Liu Pan P Yang Mei M Zou Leqin L Xiao Dingfu D
BioMed research international 20201020
The antioxidant function and metabolic profiles in mice after dietary supplementation with methionine were investigated. The results showed that methionine supplementation enhanced liver GSH-Px activity and upregulated Gpx1 expression in the liver and SOD1 and Gpx4 expressions in the jejunum. Nrf2/Keap1 is involved in oxidative stress, and the western blotting data exhibited that dietary methionine markedly increased Keap1 abundance, while failed to influence the Nrf2 signal. Metabolomics invest ...[more]
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