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Renin-Angiotensin System Inhibitors in COVID-19: Current Concepts.


ABSTRACT: The functional receptor to SARS-CoV-2, the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, is angiotensin-converting enzyme-2 (ACE-2), the same enzyme that physiologically counters the renin-angiotensin system (RAS) activation. Some researchers have questioned RAS inhibitors' safety in COVID-19 patients since these drugs have demonstrated an increase in ACE-2 expression in preclinical studies; therefore, they may facilitate viral invasion. On the contrary, others have hypothesized a protective role of RAS inhibitors against COVID-19-associated lung injury. Overall, the data are grossly inadequate to reach any conclusion since no human trials have yet evaluated the effects of RAS inhibitors in COVID-19. We review the current data and pathophysiological mechanisms behind this intriguing interplay between the RAS inhibitors and the COVID-19.

SUBMITTER: Mahajan K 

PROVIDER: S-EPMC7596458 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Renin-Angiotensin System Inhibitors in COVID-19: Current Concepts.

Mahajan Kunal K   Chand Negi Prakash P   Ganju Neeraj N   Sondhi Sachin S   Gaur Naresh N   Somendra Rao R  

International journal of hypertension 20201021


The functional receptor to SARS-CoV-2, the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, is angiotensin-converting enzyme-2 (ACE-2), the same enzyme that physiologically counters the renin-angiotensin system (RAS) activation. Some researchers have questioned RAS inhibitors' safety in COVID-19 patients since these drugs have demonstrated an increase in ACE-2 expression in preclinical studies; therefore, they may facilitate viral invasion. On the contrary, others have hyp  ...[more]

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