Ontology highlight
ABSTRACT:
SUBMITTER: Liu JH
PROVIDER: S-EPMC7596714 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Liu Ji-Hong JH Wang Qian Q You Qiang-Long QL Li Ze-Lin ZL Hu Neng-Yuan NY Wang Yan Y Jin Zeng-Lin ZL Li Shu-Ji SJ Li Xiao-Wen XW Yang Jian-Ming JM Zhu Xin-Hong XH Dai Yi-Fan YF Xu Jiang-Ping JP Bai Xiao-Chun XC Gao Tian-Ming TM
Nature communications 20201029 1
Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic acid (DHA). However, the impact of EPA and DHA supplementation on normal cognitive function and the molecular targets of EPA and DHA are still unknown. We show that acute administration of EPA impairs learning and memory and hippocampal LTP in adult and prepubescent mice. Similar deficits are duplicated by endogenou ...[more]