Ontology highlight
ABSTRACT:
SUBMITTER: Demontis D
PROVIDER: S-EPMC7596896 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Demontis Ditte D Rajagopal Veera Manikandan VM Thorgeirsson Thorgeir E TE Als Thomas D TD Grove Jakob J Leppälä Kalle K Gudbjartsson Daniel F DF Pallesen Jonatan J Hjorthøj Carsten C Reginsson Gunnar W GW Tyrfingsson Thorarinn T Runarsdottir Valgerdur V Qvist Per P Christensen Jane Hvarregaard JH Bybjerg-Grauholm Jonas J Bækvad-Hansen Marie M Huckins Laura M LM Stahl Eli A EA Timmermann Allan A Agerbo Esben E Hougaard David M DM Werge Thomas T Mors Ole O Mortensen Preben Bo PB Nordentoft Merete M Daly Mark J MJ Stefansson Hreinn H Stefansson Kari K Nyegaard Mette M Børglum Anders D AD
Nature neuroscience 20190617 7
Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 cases and 48,985 controls, followed by replication in 5,501 cases and 301,041 controls. We report a genome-wide significant risk locus for CUD (P = 9.31 × 10<sup>-12</sup>) that repli ...[more]