The predicting role of circulating tumor DNA landscape in gastric cancer patients treated with immune checkpoint inhibitors.
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ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC7596978 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
The predicting role of circulating tumor DNA landscape in gastric cancer patients treated with immune checkpoint inhibitors.
Jin Ying Y Chen Dong-Liang DL Wang Feng F Yang Chao-Pin CP Chen Xu-Xian XX You Jin-Qi JQ Huang Jin-Sheng JS Shao Yang Y Zhu Dong-Qin DQ Ouyang Yu-Ming YM Luo Hui-Yan HY Wang Zhi-Qiang ZQ Wang Feng-Hua FH Li Yu-Hong YH Xu Rui-Hua RH Zhang Dong-Sheng DS
Molecular cancer 20201030 1
A more common and noninvasive predicting biomarker for programmed cell death 1 (PD-1) antibody remains to be explored. We assessed 46 patients with advanced gastric cancer who received PD-1 antibody immunotherapy and 425-genes next-generation sequencing (NGS) testing. Patients who had a > 25% decline in maximal somatic variant allelic frequency (maxVAF) had a longer progression free survival (PFS) and higher response rate than those who did not (7.3 months vs 3.6 months, p = 0.0011; 53.3% vs 13. ...[more]
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