Ontology highlight
ABSTRACT:
SUBMITTER: Valin A
PROVIDER: S-EPMC7596982 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Valin Alvaro A Del Rey Manuel J MJ Municio Cristina C Usategui Alicia A Romero Marina M Fernández-Felipe Jesús J Cañete Juan D JD Blanco Francisco J FJ Ruano Yolanda Y Criado Gabriel G Pablos José L JL
BMC molecular and cell biology 20201030 1
<h4>Introduction</h4>The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target to IL6/sIL6R signal is not well characterized. The purpose of the study was to characterize the crosstalk between TNFα and IL6/sIL6R signaling to the effector pro-inflammatory response of SF.<h4>Methods</h4>SF lines were stimulated with either TNFα, ...[more]