Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infection.

ABSTRACT: SARS-CoV-2 is the etiological agent of COVID-19 and responsible for more than 6 million cases globally, for which no vaccine or antiviral is available. Therefore, this study was planned to investigate the antiviral role of the active constituents against spike glycoprotein of SARS-CoV-2 as well as its host ACE2 receptor. Structure-based drug design approach has been used to elucidate the antiviral activity of active constituents present in traditional medicinal plants from Ayurveda. Further, parameters like drug-likeness, pharmacokinetics, and toxicity were determined to ensure the safety and efficacy of active constituents. Gene network analysis was performed to investigate the pathways altered during COVID-19. The prediction of drug-target interactions was performed to discover novel tar

SUBMITTER: Maurya VK 

PROVIDER: S-EPMC7597308 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature