Ontology highlight
ABSTRACT:
SUBMITTER: Xu K
PROVIDER: S-EPMC7598939 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Xu Ke K Li Boyang B McGinnis Kathleen A KA Vickers-Smith Rachel R Dao Cecilia C Sun Ning N Kember Rachel L RL Zhou Hang H Becker William C WC Gelernter Joel J Kranzler Henry R HR Zhao Hongyu H Justice Amy C AC
Nature communications 20201020 1
Here we report a large genome-wide association study (GWAS) for longitudinal smoking phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we identified 18 loci for smoking trajectory of current versus never in European Americans, one locus in African Americans, and one in Hispanic Americans. Functional annotations prioritized several dozen genes where significant loci co-localized with either expression quantitative trait loci or chromatin interactions. The smoking traj ...[more]