Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants.
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SUBMITTER: Zhao X
PROVIDER: S-EPMC7598941 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants.
Zhao Xutong X Qiao Dandi D Yang Chaojie C Kasela Silva S Kim Wonji W Ma Yanlin Y Shrine Nick N Batini Chiara C Sofer Tamar T Taliun Sarah A Gagliano SAG Sakornsakolpat Phuwanat P Balte Pallavi P PP Prokopenko Dmitry D Yu Bing B Lange Leslie A LA Dupuis Josée J Cade Brian E BE Lee Jiwon J Gharib Sina A SA Daya Michelle M Laurie Cecelia A CA Ruczinski Ingo I Cupples L Adrienne LA Loehr Laura R LR Bartz Traci M TM Morrison Alanna C AC Psaty Bruce M BM Vasan Ramachandran S RS Wilson James G JG Taylor Kent D KD Durda Peter P Johnson W Craig WC Cornell Elaine E Guo Xiuqing X Liu Yongmei Y Tracy Russell P RP Ardlie Kristin G KG Aguet François F VanDenBerg David J DJ Papanicolaou George J GJ Rotter Jerome I JI Barnes Kathleen C KC Jain Deepti D Nickerson Deborah A DA Muzny Donna M DM Metcalf Ginger A GA Doddapaneni Harshavardhan H Dugan-Perez Shannon S Gupta Namrata N Gabriel Stacey S Rich Stephen S SS O'Connor George T GT Redline Susan S Reed Robert M RM Laurie Cathy C CC Daviglus Martha L ML Preudhomme Liana K LK Burkart Kristin M KM Kaplan Robert C RC Wain Louise V LV Tobin Martin D MD London Stephanie J SJ Lappalainen Tuuli T Oelsner Elizabeth C EC Abecasis Goncalo R GR Silverman Edwin K EK Barr R Graham RG Cho Michael H MH Manichaikul Ani A
Nature communications 20201014 1
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a leading cause of morbidity and mortality. We performed whole genome sequence (WGS) analysis of lung function and COPD in a multi-ethnic sample of 11,497 participants from population- and family-based studies, and 8499 individuals from COPD-enriched studies in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program. We identify at genome-wide significance 10 known GWAS loci and 22 distinct, previously unr ...[more]
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