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Imaging cardiac innervation in hereditary transthyretin (ATTRm) amyloidosis: A marker for neuropathy or cardiomyopathy in case of heart failure?


ABSTRACT: BACKGROUND:Nuclear imaging modalities using 123Iodine-metaiodobenzylguanidine (123I-MIBG) and bone seeking tracers identify early cardiac involvement in ATTRm amyloidosis patients. However, little is known whether results from 123I-MIBG scintigraphy actually correlate to markers for either cardiac autonomic neuropathy or cardiomyopathy. METHODS:All TTR mutation carriers and ATTRm patients who underwent both 123I-MIBG and 99mTechnetium-hydroxymethylene diphosphonate (99mTc-HDP) scintigraphy were included. Cardiomyopathy was defined as NT-proBNP?>?365 ng/L, and cardiac autonomic neuropathy as abnormal cardiovascular reflexes at autonomic function tests. Late 123I-MIBG heart-to-mediastinum ratio (HMR)??20%, and any cardiac 99mTc-HDP uptake were considered as abnormal. RESULTS:39 patients (13 carriers and 26 ATTRm patients) were included in this study. Patients with cardiomyopathy, with or without cardiac autonomic neuropathy, had lower late HMR than similar patients without cardiomyopathy [median 1.1 (range 1.0-1.5) and 1.5(1.2-2.6) vs 2.4 (1.4-3.8) and 2.5 (1.5-3.7), respectively, P?

SUBMITTER: Jonker DL 

PROVIDER: S-EPMC7599160 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Imaging cardiac innervation in hereditary transthyretin (ATTRm) amyloidosis: A marker for neuropathy or cardiomyopathy in case of heart failure?

Jonker Daphne L DL   Hazenberg Bouke P C BPC   Nienhuis Hans L A HLA   Slart Riemer H J A RHJA   Glaudemans Andor W J M AWJM   Noordzij Walter W  

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20181029 5


<h4>Background</h4>Nuclear imaging modalities using <sup>123</sup>Iodine-metaiodobenzylguanidine (<sup>123</sup>I-MIBG) and bone seeking tracers identify early cardiac involvement in ATTRm amyloidosis patients. However, little is known whether results from <sup>123</sup>I-MIBG scintigraphy actually correlate to markers for either cardiac autonomic neuropathy or cardiomyopathy.<h4>Methods</h4>All TTR mutation carriers and ATTRm patients who underwent both <sup>123</sup>I-MIBG and <sup>99m</sup>Te  ...[more]

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