Early Post-Operative Pancreatitis and Systemic Inflammatory Response Assessed by Serum Lipase and IL-6 Predict Pancreatic Fistula.

ABSTRACT: BACKGROUND:Post-operative pancreatic fistula (POPF) remains a critical complication after pancreatic resection. This prospective pilot study evaluates perioperative markers of pancreatitis and systemic inflammation to predict clinically relevant grade B/C-POPF (CR-POPF). METHODS:All patients undergoing pancreatic resection from December 2017 to April 2019 were prospectively enrolled. Surgical procedures and outcomes were correlated with perioperative blood markers. ROC analysis was performed to assess their predictive value for CR-POPF. Cut-offs were calculated with the Youden index. RESULTS:In total, 70 patients were analysed (43 pancreatoduodenectomies and 27 distal pancreatectomies). In-hospital/90-d mortality and morbidity were 5.7/7.1% (n?=?4/n?=?5) and 75.7% (n?=?53). Major complications (Clavien-Dindo???3a) occurred in 28 (40.0%) patients, CR-POPF in 20 (28.6%) patients. Serum lipase (cut-off?>?51U/L) and IL-6 (>?56.5 ng/l) on POD3 were significant predictors for CR-POPF (AUC?=?0.799, 95%-CI 0.686-0.912 and AUC?=?0.784, 95%-CI 0.668-0.900; combined AUC?=?0.858, 95%-CI 0.758-0.958; all p?

SUBMITTER: Gasteiger S 

PROVIDER: S-EPMC7599180 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature