Nrf2 in Neoplastic and Non-Neoplastic Liver Diseases.
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ABSTRACT:
SUBMITTER: Orru C
PROVIDER: S-EPMC7599585 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Nrf2 in Neoplastic and Non-Neoplastic Liver Diseases.
Orrù Claudia C Giordano Silvia S Columbano Amedeo A
Cancers 20201012 10
Activation of the Keap1/Nrf2 pathway, the most important cell defense signal, triggered to neutralize the harmful effects of electrophilic and oxidative stress, plays a crucial role in cell survival. Therefore, its ability to attenuate acute and chronic liver damage, where oxidative stress represents the key player, is not surprising. On the other hand, while Nrf2 promotes proliferation in cancer cells, its role in non-neoplastic hepatocytes is a matter of debate. Another topic of uncertainty co ...[more]
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