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Discovery of a Novel Simian Pegivirus in Common Marmosets (Callithrix jacchus) with Lymphocytic Enterocolitis.


ABSTRACT: From 2010 to 2015, 73 common marmosets (Callithrix jacchus) housed at the Wisconsin National Primate Research Center (WNPRC) were diagnosed postmortem with lymphocytic enterocolitis. We used unbiased deep-sequencing to screen the blood of deceased enterocolitis-positive marmosets for viruses. In five out of eight common marmosets with lymphocytic enterocolitis, we discovered a novel pegivirus not present in ten matched, clinically normal controls. The novel virus, which we named Southwest bike trail virus (SOBV), is most closely related (68% nucleotide identity) to a strain of simian pegivirus A isolated from a three-striped night monkey (Aotus trivirgatus). We screened 146 living WNPRC common marmosets for SOBV, finding an overall prevalence of 34% (50/146). Over four years, 85 of these 146 animals died or were euthanized. Histological examination revealed 27 SOBV-positive marmosets from this cohort had lymphocytic enterocolitis, compared to 42 SOBV-negative marmosets, indicating no association between SOBV and disease in this cohort (p = 0.0798). We also detected SOBV in two of 33 (6%) clinically normal marmosets screened during transfer from the New England Primate Research Center, suggesting SOBV could be exerting confounding influences on comparisons of common marmoset studies from multiple colonies.

SUBMITTER: Heffron AS 

PROVIDER: S-EPMC7599636 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Discovery of a Novel Simian Pegivirus in Common Marmosets (<i>Callithrix jacchus</i>) with Lymphocytic Enterocolitis.

Heffron Anna S AS   Lauck Michael M   Somsen Elizabeth D ED   Townsend Elizabeth C EC   Bailey Adam L AL   Sosa Megan M   Eickhoff Jens J   Capuano Iii Saverio S   Newman Christina M CM   Kuhn Jens H JH   Mejia Andres A   Simmons Heather A HA   O'Connor David H DH  

Microorganisms 20200930 10


From 2010 to 2015, 73 common marmosets (<i>Callithrix jacchus</i>) housed at the Wisconsin National Primate Research Center (WNPRC) were diagnosed postmortem with lymphocytic enterocolitis. We used unbiased deep-sequencing to screen the blood of deceased enterocolitis-positive marmosets for viruses. In five out of eight common marmosets with lymphocytic enterocolitis, we discovered a novel pegivirus not present in ten matched, clinically normal controls. The novel virus, which we named Southwest  ...[more]

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