Ontology highlight
ABSTRACT:
SUBMITTER: Muller JP
PROVIDER: S-EPMC7600363 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Müller Jörg P JP Schmidt-Arras Dirk D
Cancers 20200929 10
Fms-like tyrosine kinase 3 (FLT3) is a member of the class III receptor tyrosine kinases (RTK) and is involved in cell survival, proliferation, and differentiation of haematopoietic progenitors of lymphoid and myeloid lineages. Oncogenic mutations in the FLT3 gene resulting in constitutively active FLT3 variants are frequently found in acute myeloid leukaemia (AML) patients and correlate with patient's poor survival. Targeting FLT3 mutant leukaemic stem cells (LSC) is a key to efficient treatmen ...[more]