Ontology highlight
ABSTRACT:
SUBMITTER: Lafoux A
PROVIDER: S-EPMC7600525 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Lafoux Aude A Lotteau Sabine S Huchet Corinne C Ducreux Sylvie S
Life (Basel, Switzerland) 20201006 10
The transient receptor potential vanilloid 1 (TRPV1) belongs to the transient receptor potential superfamily of sensory receptors. TRPV1 is a non-selective cation channel permeable to Ca<sup>2+</sup> that is capable of detecting noxious heat temperature and acidosis. In skeletal muscles, TRPV1 operates as a reticular Ca<sup>2+</sup>-leak channel and several <i>TRPV1</i> mutations have been associated with two muscle disorders: malignant hyperthermia (MH) and exertional heat stroke (EHS). Althoug ...[more]