Ontology highlight
ABSTRACT:
SUBMITTER: Olson A
PROVIDER: S-EPMC7600714 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Olson Alex A Basukala Binita B Lee Seunghee S Gagne Matthew M Wong Wilson W WW Henderson Andrew J AJ
Viruses 20201012 10
The major barrier to HIV-1 cure is the persistence of latent provirus, which is not eradicated by antiretroviral therapy. The "shock and kill" approach entails stimulating viral production with latency-reversing agents followed by the killing of cells actively producing the virus by immune clearance. However, this approach does not induce all intact proviruses, leaving a residual reservoir. CRISPR/Cas9 has been utilized to excise integrated Human Immunodeficiency Virus (HIV) DNA from infected ce ...[more]